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A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures

We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is composed of four coupled sub-models: (1) the static finite elastic...

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Detalles Bibliográficos
Autores principales: Colli Franzone, Piero, Pavarino, Luca F., Scacchi, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895745/
https://www.ncbi.nlm.nih.gov/pubmed/29674971
http://dx.doi.org/10.3389/fphys.2018.00268
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author Colli Franzone, Piero
Pavarino, Luca F.
Scacchi, Simone
author_facet Colli Franzone, Piero
Pavarino, Luca F.
Scacchi, Simone
author_sort Colli Franzone, Piero
collection PubMed
description We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is composed of four coupled sub-models: (1) the static finite elasticity equations for the transversely isotropic deformation of the cardiac tissue; (2) the active tension model describing the dynamics of the intracellular calcium, cross-bridge binding and myofilament tension; (3) the anisotropic Bidomain model describing the evolution of the intra- and extra-cellular potentials in the deforming cardiac tissue; and (4) the ionic membrane model describing the dynamics of ionic currents, gating variables, ionic concentrations and stretch-activated channels. This strongly coupled electro-mechanical model is discretized in time with a splitting semi-implicit technique and in space with isoparametric finite elements. The resulting scalable parallel solver is based on Multilevel Additive Schwarz preconditioners for the solution of the Bidomain system and on BDDC preconditioned Newton-Krylov solvers for the non-linear finite elasticity system. The results of several 3D parallel simulations show the scalability of both linear and non-linear solvers and their application to the study of both physiological excitation-contraction cardiac dynamics and re-entrant waves in the presence of different mechano-electrical feedbacks.
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spelling pubmed-58957452018-04-19 A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures Colli Franzone, Piero Pavarino, Luca F. Scacchi, Simone Front Physiol Physiology We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is composed of four coupled sub-models: (1) the static finite elasticity equations for the transversely isotropic deformation of the cardiac tissue; (2) the active tension model describing the dynamics of the intracellular calcium, cross-bridge binding and myofilament tension; (3) the anisotropic Bidomain model describing the evolution of the intra- and extra-cellular potentials in the deforming cardiac tissue; and (4) the ionic membrane model describing the dynamics of ionic currents, gating variables, ionic concentrations and stretch-activated channels. This strongly coupled electro-mechanical model is discretized in time with a splitting semi-implicit technique and in space with isoparametric finite elements. The resulting scalable parallel solver is based on Multilevel Additive Schwarz preconditioners for the solution of the Bidomain system and on BDDC preconditioned Newton-Krylov solvers for the non-linear finite elasticity system. The results of several 3D parallel simulations show the scalability of both linear and non-linear solvers and their application to the study of both physiological excitation-contraction cardiac dynamics and re-entrant waves in the presence of different mechano-electrical feedbacks. Frontiers Media S.A. 2018-04-05 /pmc/articles/PMC5895745/ /pubmed/29674971 http://dx.doi.org/10.3389/fphys.2018.00268 Text en Copyright © 2018 Colli Franzone, Pavarino and Scacchi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Colli Franzone, Piero
Pavarino, Luca F.
Scacchi, Simone
A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title_full A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title_fullStr A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title_full_unstemmed A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title_short A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
title_sort numerical study of scalable cardiac electro-mechanical solvers on hpc architectures
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895745/
https://www.ncbi.nlm.nih.gov/pubmed/29674971
http://dx.doi.org/10.3389/fphys.2018.00268
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