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Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome

Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1, or PTEN, which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling...

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Detalles Bibliográficos
Autores principales:	Asano, Takaki, Okada, Satoshi, Tsumura, Miyuki, Yeh, Tzu-Wen, Mitsui-Sekinaka, Kanako, Tsujita, Yuki, Ichinose, Youjiro, Shimada, Akira, Hashimoto, Kunio, Wada, Taizo, Imai, Kohsuke, Ohara, Osamu, Morio, Tomohiro, Nonoyama, Shigeaki, Kobayashi, Masao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895775/ https://www.ncbi.nlm.nih.gov/pubmed/29675019 http://dx.doi.org/10.3389/fimmu.2018.00568

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