Peripherally Administered Y(2)-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice

Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level of central and sympathetic nervous systems (SNSs). Genetic silencing of peripheral Y(2)-receptors have anti-obesity effects, but it is not known whether pharmacological blocking of peripheral Y(2)-recep...

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Detalles Bibliográficos
Autores principales: Ailanen, Liisa, Vähätalo, Laura H., Salomäki-Myftari, Henriikka, Mäkelä, Satu, Orpana, Wendy, Ruohonen, Suvi T., Savontaus, Eriika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895854/
https://www.ncbi.nlm.nih.gov/pubmed/29674968
http://dx.doi.org/10.3389/fphar.2018.00319

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