The role of CKIP-1 in osteoporosis development and treatment

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone for...

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Detalles Bibliográficos
Autores principales: Peng, X., Wu, X., Zhang, J., Zhang, G., Li, G., Pan, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Systematic Review: Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895943/
https://www.ncbi.nlm.nih.gov/pubmed/29682283
http://dx.doi.org/10.1302/2046-3758.72.BJR-2017-0172.R1
Descripción
Sumario:Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.

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