The role of CKIP-1 in osteoporosis development and treatment

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone for...

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Detalles Bibliográficos
Autores principales: Peng, X., Wu, X., Zhang, J., Zhang, G., Li, G., Pan, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Systematic Review: Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895943/
https://www.ncbi.nlm.nih.gov/pubmed/29682283
http://dx.doi.org/10.1302/2046-3758.72.BJR-2017-0172.R1
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author Peng, X.
Wu, X.
Zhang, J.
Zhang, G.
Li, G.
Pan, X.
author_facet Peng, X.
Wu, X.
Zhang, J.
Zhang, G.
Li, G.
Pan, X.
author_sort Peng, X.
collection PubMed
description Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.
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spelling pubmed-58959432018-04-20 The role of CKIP-1 in osteoporosis development and treatment Peng, X. Wu, X. Zhang, J. Zhang, G. Li, G. Pan, X. Bone Joint Res Systematic Review: Research Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1. 2018-04-12 /pmc/articles/PMC5895943/ /pubmed/29682283 http://dx.doi.org/10.1302/2046-3758.72.BJR-2017-0172.R1 Text en © 2018 Peng et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
spellingShingle Systematic Review: Research
Peng, X.
Wu, X.
Zhang, J.
Zhang, G.
Li, G.
Pan, X.
The role of CKIP-1 in osteoporosis development and treatment
title The role of CKIP-1 in osteoporosis development and treatment
title_full The role of CKIP-1 in osteoporosis development and treatment
title_fullStr The role of CKIP-1 in osteoporosis development and treatment
title_full_unstemmed The role of CKIP-1 in osteoporosis development and treatment
title_short The role of CKIP-1 in osteoporosis development and treatment
title_sort role of ckip-1 in osteoporosis development and treatment
topic Systematic Review: Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895943/
https://www.ncbi.nlm.nih.gov/pubmed/29682283
http://dx.doi.org/10.1302/2046-3758.72.BJR-2017-0172.R1
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