Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

[Image: see text] The core of the loline family of insecticidal alkaloids is the bicyclic pyrrolizidine unit with an additional strained ether bridge between carbons 2 and 7. Previously reported genetic and in vivo biochemical analyses showed that the presumptive iron- and 2-oxoglutarate-dependent (...

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Detalles Bibliográficos
Autores principales: Pan, Juan, Bhardwaj, Minakshi, Zhang, Bo, Chang, Wei-chen, Schardl, Christopher L., Krebs, Carsten, Grossman, Robert B., Bollinger, J. Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895980/
https://www.ncbi.nlm.nih.gov/pubmed/29537853
http://dx.doi.org/10.1021/acs.biochem.8b00157

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