Cargando…

Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer

BACKGROUND: Breast cancer is the most frequent cancer among women worldwide. Biomarkers for early detection and prognosis of these patients are needed. We hypothesized that deafness, autosomal dominant 5 (DFNA5) may be a valuable biomarker, based upon strong indications for its role as tumor suppres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Croes, Lieselot, Beyens, Matthias, Fransen, Erik, Ibrahim, Joe, Vanden Berghe, Wim, Suls, Arvid, Peeters, Marc, Pauwels, Patrick, Van Camp, Guy, Op de Beeck, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896072/ https://www.ncbi.nlm.nih.gov/pubmed/29682089 http://dx.doi.org/10.1186/s13148-018-0479-y

Ejemplares similares

DFNA5 promoter methylation a marker for breast tumorigenesis
por: Croes, Lieselot, et al.
Publicado: (2017)

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer
por: Ibrahim, Joe, et al.
Publicado: (2019)

Role of DFNA5 in hearing loss and cancer – a comment on Rakusic et al
por: Croes, Lieselot, et al.
Publicado: (2015)

Large-scale copy number analysis reveals variations in genes not previously associated with malignant pleural mesothelioma
por: Hylebos, Marieke, et al.
Publicado: (2017)

Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model
por: Croes, Lieselot, et al.
Publicado: (2019)

Genome‐wide DNA methylation profiling and identification of potential pan‐cancer and tumor‐specific biomarkers
por: Ibrahim, Joe, et al.
Publicado: (2022)

The Gasdermin E Gene Has Potential as a Pan-Cancer Biomarker, While Discriminating between Different Tumor Types
por: Ibrahim, Joe, et al.
Publicado: (2019)

The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways
por: Van Rossom, Sofie, et al.
Publicado: (2015)

Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs
por: Janssens, Katleen, et al.
Publicado: (2023)

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer
por: Limame, Ridha, et al.
Publicado: (2013)

pyAmpli: an amplicon-based variant filter pipeline for targeted resequencing data
por: Beyens, Matthias, et al.
Publicado: (2017)

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae
por: Van Rossom, Sofie, et al.
Publicado: (2012)

A Belgian Population-Based Study Reveals Subgroups of Right-sided Colorectal Cancer with a Better Prognosis Compared to Left-sided Cancer
por: Janssens, Katleen, et al.
Publicado: (2023)

Cell-Free DNA From Metastatic Pancreatic Neuroendocrine Tumor Patients Contains Tumor-Specific Mutations and Copy Number Variations
por: Boons, Gitta, et al.
Publicado: (2018)

Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors
por: Vandamme, Timon, et al.
Publicado: (2016)

Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
por: Szarc vel Szic, Katarzyna, et al.
Publicado: (2014)

PDX1 DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis
por: Boons, Gitta, et al.
Publicado: (2020)

Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells
por: Palagani, Ajay, et al.
Publicado: (2014)

Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders
por: Declerck, Ken, et al.
Publicado: (2019)

MDM2 SNP309 and SNP285 Act as Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients
por: Deben, Christophe, et al.
Publicado: (2017)

Genetics of hearing loss: focus on DFNA2
por: Dominguez, Laura M, et al.
Publicado: (2012)

New Insights into the Identity of the DFNA58 Gene
por: do Nascimento, Larissa Reis, et al.
Publicado: (2022)

Unraveling haplotype errors in the DFNA33 locus
por: Vona, Barbara, et al.
Publicado: (2023)

Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study
por: Declerck, Ken, et al.
Publicado: (2017)

Longitudinal Copy-Number Alteration Analysis in Plasma Cell-Free DNA of Neuroendocrine Neoplasms is a Novel Specific Biomarker for Diagnosis, Prognosis, and Follow-up
por: Boons, Gitta, et al.
Publicado: (2022)

Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy
por: Langie, Sabine A. S., et al.
Publicado: (2016)

Correction: Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy
por: Langie, Sabine A. S., et al.
Publicado: (2017)

Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences
por: Declerck, Ken, et al.
Publicado: (2021)

Confirmation of GRHL2 as the gene for the DFNA28 locus
por: Vona, Barbara, et al.
Publicado: (2013)

DFNA5 regulates immune cells infiltration and exhaustion
por: Hu, Jian, et al.
Publicado: (2022)

Genotype-phenotype Correlation Study in a Large Series of Patients Carrying the p.Pro51Ser (p.P51S) Variant in COCH (DFNA9): Part I—A Cross-sectional Study of Hearing Function in 111 Carriers
por: JanssensdeVarebeke, Sebastien P. F., et al.
Publicado: (2021)

Genotype-Phenotype Correlation Study in a Large Series of Patients Carrying the p.Pro51Ser (p.P51S) Variant in COCH (DFNA9) Part II: A Prospective Cross-Sectional Study of the Vestibular Phenotype in 111 Carriers
por: JanssensdeVarebeke, Sebastien P. F., et al.
Publicado: (2021)

Immunoglobin G/total antibody testing for SARS-CoV-2: A prospective cohort study of ambulatory patients and health care workers in two Belgian oncology units comparing three commercial tests
por: van Dam, Peter, et al.
Publicado: (2021)

Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer Patients
por: De Winter, Fien H. R., et al.
Publicado: (2021)

Krüppel-like factors in cancer progression: three fingers on the steering wheel
por: Limame, Ridha, et al.
Publicado: (2013)

Further evidence for “gain-of-function” mechanism of DFNA5 related hearing loss
por: Wang, Hongyang, et al.
Publicado: (2018)

Correlations Between Vestibular Function and Imaging of the Semicircular Canals in DFNA9 Patients
por: Ihtijarevic, Berina, et al.
Publicado: (2020)

Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification
por: Langie, Sabine A. S., et al.
Publicado: (2017)

A novel dominant GJB2 (DFNA3) mutation in a Chinese family
por: Wang, Hongyang, et al.
Publicado: (2017)

Insights into the pathophysiology of DFNA10 hearing loss associated with novel EYA4 variants
por: Morín, Matias, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_app58rr8ch2jenvu116qkm94vn