Cargando…

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

BACKGROUND: Thirty to 40 % of non-small cell lung cancer (NSCLC) patients developed higher hypertriglyceridemia in the process of treatment with bexarotene. And bioinformatics studies discovered that the expression of slc10a2 was increased in high-grade hypertriglyceridemia patients. So, we will exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ai, Xinghao, Mao, Feng, Shen, Shengping, Shentu, Yang, Wang, Jiejun, Lu, Shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896077/ https://www.ncbi.nlm.nih.gov/pubmed/29642873 http://dx.doi.org/10.1186/s12885-018-4224-x

Ejemplares similares

Identification of Bexarotene as a PPARγ Antagonist with HDX
por: Marciano, David P., et al.
Publicado: (2015)

PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis
por: Dell'Accio, Francesco, et al.
Publicado: (2015)

PPARγ/mTOR Regulates the Synthesis and Release of Prostaglandins in Ovine Trophoblast Cells in Early Pregnancy
por: Hao, Kexing, et al.
Publicado: (2022)

PPARγ, PTEN, and the Fight against Cancer
por: Teresi, Rosemary E., et al.
Publicado: (2008)

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
por: Angela, Mulki, et al.
Publicado: (2016)

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
por: Lu, Jianjun, et al.
Publicado: (2015)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
por: Vasheghani, Faezeh, et al.
Publicado: (2015)

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β
por: Sun, Panpan, et al.
Publicado: (2022)

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line
por: Pagani, Francesca, et al.
Publicado: (2023)

Comparison of the Efficacy and Safety of Bexarotene and Photo(Chemo)Therapy Combination Therapy and Bexarotene Monotherapy for Cutaneous T-Cell Lymphoma
por: Morita, Akimichi, et al.
Publicado: (2022)

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway
por: Wu, Liwei, et al.
Publicado: (2021)

Alteration of PPAR‐GAMMA (PPARG; PPARγ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells
por: Esmaeili, Shadi, et al.
Publicado: (2021)

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis
por: Li, Xiang, et al.
Publicado: (2023)

Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB(4) After Subarachnoid Hemorrhage in Rats
por: Zhang, Zhaosi, et al.
Publicado: (2019)

Localization of αυβ6 Integrin-TGF-β1/Smad3, mTOR and PPARγ in Experimental Colorectal Fibrosis
por: Latella, G., et al.
Publicado: (2013)

Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR –PPARγ Signalling in Macrophages
por: Souza-Moreira, Luciana, et al.
Publicado: (2019)

Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas
por: Warda, Ankedo, et al.
Publicado: (2023)

NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10
por: Sun, Yingjia, et al.
Publicado: (2015)

mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines
por: Freis, Patricia, et al.
Publicado: (2017)

PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway
por: Cheng, Zhi Y, et al.
Publicado: (2008)

IFN-γ mediates Paneth cell death via suppression of mTOR
por: Araujo, Alessandra, et al.
Publicado: (2021)

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats
por: Zuo, Yuchun, et al.
Publicado: (2019)

A Novel Co-Crystal of Bexarotene and Ligustrazine Improves Pharmacokinetics and Tissue Distribution of Bexarotene in SD Rats
por: Ren, Shuyue, et al.
Publicado: (2020)

Deoxyshikonin Inhibits Viability and Glycolysis by Suppressing the Akt/mTOR Pathway in Acute Myeloid Leukemia Cells
por: Wu, Huijuan, et al.
Publicado: (2020)

Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN-Akt-mTOR autophagic pathway
por: Shi, Lungang, et al.
Publicado: (2019)

Photodegradation of Bexarotene and Its Implication for Cytotoxicity
por: Kryczyk-Poprawa, Agata, et al.
Publicado: (2021)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Detection and correlation analysis of serum cytokines in non-small-cell lung cancer patients with bone and non-bone metastases
por: Sun, Yingjia, et al.
Publicado: (2015)

miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling
por: Wu, Shi-Min, et al.
Publicado: (2019)

Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARγ expression
por: Lu, Zhen-hai, et al.
Publicado: (2018)

Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
por: del Campo, José A., et al.
Publicado: (2018)

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
por: Nguyen, Lena H., et al.
Publicado: (2023)

Lactotransferrin Downregulation Serves as a Potential Predictor for the Therapeutic Effectiveness of mTOR Inhibitors in the Metastatic Clear Cell Renal Cell Carcinoma without PTEN Mutation
por: Zheng, Jing-Quan, et al.
Publicado: (2021)

Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells
por: Das, Piyanki, et al.
Publicado: (2023)

MicroRNA-126 Inhibit Viability of Colorectal Cancer Cell by Repressing mTOR Induced Apoptosis and Autophagy
por: Wei, Li, et al.
Publicado: (2020)

The amino acid transporter Slc7a5 regulates the mTOR pathway and is required for granule cell development
por: Sokolov, Aidan M, et al.
Publicado: (2020)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

Effect of mTOR Inhibitors in Nude Mice with Endometrial Carcinoma and Variable PTEN Expression Status
por: Fong, Pedro, et al.
Publicado: (2014)

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
por: Jung, Seung Hee, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_unje78f44k81en6uej0cr07ve9