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Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896186/ https://www.ncbi.nlm.nih.gov/pubmed/29692585 http://dx.doi.org/10.4103/JLP.JLP_100_17 |
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author | Kumar, Sunil Agrawal, Sachin Raisinghani, Nitin Khan, Shameem |
author_facet | Kumar, Sunil Agrawal, Sachin Raisinghani, Nitin Khan, Shameem |
author_sort | Kumar, Sunil |
collection | PubMed |
description | INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis. MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale. RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP. CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning. |
format | Online Article Text |
id | pubmed-5896186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58961862018-04-24 Leukocyte count: A reliable marker for the severity of organophosphate intoxication? Kumar, Sunil Agrawal, Sachin Raisinghani, Nitin Khan, Shameem J Lab Physicians Original Article INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis. MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale. RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP. CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5896186/ /pubmed/29692585 http://dx.doi.org/10.4103/JLP.JLP_100_17 Text en Copyright: © 2018 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kumar, Sunil Agrawal, Sachin Raisinghani, Nitin Khan, Shameem Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title_full | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title_fullStr | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title_full_unstemmed | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title_short | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
title_sort | leukocyte count: a reliable marker for the severity of organophosphate intoxication? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896186/ https://www.ncbi.nlm.nih.gov/pubmed/29692585 http://dx.doi.org/10.4103/JLP.JLP_100_17 |
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