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Leukocyte count: A reliable marker for the severity of organophosphate intoxication?

INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the...

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Autores principales: Kumar, Sunil, Agrawal, Sachin, Raisinghani, Nitin, Khan, Shameem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896186/
https://www.ncbi.nlm.nih.gov/pubmed/29692585
http://dx.doi.org/10.4103/JLP.JLP_100_17
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author Kumar, Sunil
Agrawal, Sachin
Raisinghani, Nitin
Khan, Shameem
author_facet Kumar, Sunil
Agrawal, Sachin
Raisinghani, Nitin
Khan, Shameem
author_sort Kumar, Sunil
collection PubMed
description INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis. MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale. RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP. CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning.
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spelling pubmed-58961862018-04-24 Leukocyte count: A reliable marker for the severity of organophosphate intoxication? Kumar, Sunil Agrawal, Sachin Raisinghani, Nitin Khan, Shameem J Lab Physicians Original Article INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis. MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale. RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP. CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5896186/ /pubmed/29692585 http://dx.doi.org/10.4103/JLP.JLP_100_17 Text en Copyright: © 2018 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumar, Sunil
Agrawal, Sachin
Raisinghani, Nitin
Khan, Shameem
Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title_full Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title_fullStr Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title_full_unstemmed Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title_short Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
title_sort leukocyte count: a reliable marker for the severity of organophosphate intoxication?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896186/
https://www.ncbi.nlm.nih.gov/pubmed/29692585
http://dx.doi.org/10.4103/JLP.JLP_100_17
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