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Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and cataly...
Autores principales: | Kwasna, Dominika, Abdul Rehman, Syed Arif, Natarajan, Jayaprakash, Matthews, Stephen, Madden, Ross, De Cesare, Virginia, Weidlich, Simone, Virdee, Satpal, Ahel, Ivan, Gibbs-Seymour, Ian, Kulathu, Yogesh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896202/ https://www.ncbi.nlm.nih.gov/pubmed/29576527 http://dx.doi.org/10.1016/j.molcel.2018.02.023 |
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