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Gallnuts: A Potential Treasure in Anticancer Drug Discovery

Introduction. In the discovery of more potent and selective anticancer drugs, the research continually expands and explores new bioactive metabolites coming from different natural sources. Gallnuts are a group of very special natural products formed through parasitic interaction between plants and i...

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Autores principales: Gao, Jiayu, Yang, Xiao, Yin, Weiping, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896229/
https://www.ncbi.nlm.nih.gov/pubmed/29785193
http://dx.doi.org/10.1155/2018/4930371
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author Gao, Jiayu
Yang, Xiao
Yin, Weiping
Li, Ming
author_facet Gao, Jiayu
Yang, Xiao
Yin, Weiping
Li, Ming
author_sort Gao, Jiayu
collection PubMed
description Introduction. In the discovery of more potent and selective anticancer drugs, the research continually expands and explores new bioactive metabolites coming from different natural sources. Gallnuts are a group of very special natural products formed through parasitic interaction between plants and insects. Though it has been traditionally used as a source of drugs for the treatment of cancerous diseases in traditional and folk medicinal systems through centuries, the anticancer properties of gallnuts are barely systematically reviewed. Objective. To evidence the traditional uses and phytochemicals and pharmacological mechanisms in anticancer aspects of gallnuts, a literature review was performed. Materials and Methods. The systematic review approach consisted of searching web-based scientific databases including PubMed, Web of Science, and Science Direct. The keywords for searching include gallnut, Galla Chinensis, Rhus chinensis, Rhus potaninii, Rhus punjabensis, nutgall, gall oak, Quercus infectoria, Quercus lusitanica, and galla turcica. Two reviewers extracted papers independently to remove the papers unrelated to the anticancer properties of gallnuts. Patents, abstracts, case reports, and abstracts in symposium and congress were excluded. Results and Conclusion. As a result, 14 articles were eligible to be evaluated. It is primarily evident that gallnuts contain a number of bioactive metabolites, which account for anticancer activities. The phytochemical and pharmacological studies reviewed strongly underpin a fundamental understanding of anticancer properties for gallnuts (Galla Chinensis and Galla Turcica) and support their ongoing clinical uses in China. The further bioactive compounds screening and evaluation, pharmacological investigation, and clinical trials are expected to progress gallnut-based development to finally transform the wild medicinal gallnuts to the valuable authorized anticancer drugs.
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spelling pubmed-58962292018-05-21 Gallnuts: A Potential Treasure in Anticancer Drug Discovery Gao, Jiayu Yang, Xiao Yin, Weiping Li, Ming Evid Based Complement Alternat Med Review Article Introduction. In the discovery of more potent and selective anticancer drugs, the research continually expands and explores new bioactive metabolites coming from different natural sources. Gallnuts are a group of very special natural products formed through parasitic interaction between plants and insects. Though it has been traditionally used as a source of drugs for the treatment of cancerous diseases in traditional and folk medicinal systems through centuries, the anticancer properties of gallnuts are barely systematically reviewed. Objective. To evidence the traditional uses and phytochemicals and pharmacological mechanisms in anticancer aspects of gallnuts, a literature review was performed. Materials and Methods. The systematic review approach consisted of searching web-based scientific databases including PubMed, Web of Science, and Science Direct. The keywords for searching include gallnut, Galla Chinensis, Rhus chinensis, Rhus potaninii, Rhus punjabensis, nutgall, gall oak, Quercus infectoria, Quercus lusitanica, and galla turcica. Two reviewers extracted papers independently to remove the papers unrelated to the anticancer properties of gallnuts. Patents, abstracts, case reports, and abstracts in symposium and congress were excluded. Results and Conclusion. As a result, 14 articles were eligible to be evaluated. It is primarily evident that gallnuts contain a number of bioactive metabolites, which account for anticancer activities. The phytochemical and pharmacological studies reviewed strongly underpin a fundamental understanding of anticancer properties for gallnuts (Galla Chinensis and Galla Turcica) and support their ongoing clinical uses in China. The further bioactive compounds screening and evaluation, pharmacological investigation, and clinical trials are expected to progress gallnut-based development to finally transform the wild medicinal gallnuts to the valuable authorized anticancer drugs. Hindawi 2018-03-29 /pmc/articles/PMC5896229/ /pubmed/29785193 http://dx.doi.org/10.1155/2018/4930371 Text en Copyright © 2018 Jiayu Gao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gao, Jiayu
Yang, Xiao
Yin, Weiping
Li, Ming
Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title_full Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title_fullStr Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title_full_unstemmed Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title_short Gallnuts: A Potential Treasure in Anticancer Drug Discovery
title_sort gallnuts: a potential treasure in anticancer drug discovery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896229/
https://www.ncbi.nlm.nih.gov/pubmed/29785193
http://dx.doi.org/10.1155/2018/4930371
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