Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of nine hCD40 mAbs engaging epitopes throughout the CD...

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Detalles Bibliográficos
Autores principales: Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896247/
https://www.ncbi.nlm.nih.gov/pubmed/29576376
http://dx.doi.org/10.1016/j.ccell.2018.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896247/
https://www.ncbi.nlm.nih.gov/pubmed/29576376
http://dx.doi.org/10.1016/j.ccell.2018.02.009

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