GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here, we establish that GKAP governs invasive growth and treatment response to...

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Detalles Bibliográficos
Autores principales: Li, Leanne, Zeng, Qiqun, Bhutkar, Arjun, Galván, José A., Karamitopoulou, Eva, Noordermeer, Daan, Peng, Mei-Wen, Piersigilli, Alessandra, Perren, Aurel, Zlobec, Inti, Robinson, Hugh, Iruela-Arispe, M. Luisa, Hanahan, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896248/
https://www.ncbi.nlm.nih.gov/pubmed/29606348
http://dx.doi.org/10.1016/j.ccell.2018.02.011

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