Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence

Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant o...

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Detalles Bibliográficos
Autores principales: Kuba, Adam, Raida, Ludek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896258/
https://www.ncbi.nlm.nih.gov/pubmed/29785172
http://dx.doi.org/10.1155/2018/9451950
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author Kuba, Adam
Raida, Ludek
author_facet Kuba, Adam
Raida, Ludek
author_sort Kuba, Adam
collection PubMed
description Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence.
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spelling pubmed-58962582018-05-21 Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence Kuba, Adam Raida, Ludek Mediators Inflamm Review Article Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. Hindawi 2018-03-26 /pmc/articles/PMC5896258/ /pubmed/29785172 http://dx.doi.org/10.1155/2018/9451950 Text en Copyright © 2018 Adam Kuba and Ludek Raida. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kuba, Adam
Raida, Ludek
Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title_full Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title_fullStr Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title_full_unstemmed Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title_short Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
title_sort graft versus host disease: from basic pathogenic principles to dna damage response and cellular senescence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896258/
https://www.ncbi.nlm.nih.gov/pubmed/29785172
http://dx.doi.org/10.1155/2018/9451950
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