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Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases

Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-med...

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Detalles Bibliográficos
Autores principales: Tan, Wanyan, Wang, Wei, Ma, Qingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896335/
https://www.ncbi.nlm.nih.gov/pubmed/29789787
http://dx.doi.org/10.1155/2018/3819719
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author Tan, Wanyan
Wang, Wei
Ma, Qingfeng
author_facet Tan, Wanyan
Wang, Wei
Ma, Qingfeng
author_sort Tan, Wanyan
collection PubMed
description Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-mediated mRNA decay. The maintenance of cellular and tissue homeostasis relies on accurate alternative splicing, and various patterns of abnormal alternative splicing can cause different diseases. SRSF4 is associated with many physiological and pathological processes and has applications in the diagnosis and prognosis of specific diseases. In this review, we discuss knowledge of SRSF4 in physiological and pathological processes and highlight the applications of SRSF4 in the regulation of gene expression and associated diseases.
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spelling pubmed-58963352018-05-22 Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases Tan, Wanyan Wang, Wei Ma, Qingfeng Biomed Res Int Review Article Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-mediated mRNA decay. The maintenance of cellular and tissue homeostasis relies on accurate alternative splicing, and various patterns of abnormal alternative splicing can cause different diseases. SRSF4 is associated with many physiological and pathological processes and has applications in the diagnosis and prognosis of specific diseases. In this review, we discuss knowledge of SRSF4 in physiological and pathological processes and highlight the applications of SRSF4 in the regulation of gene expression and associated diseases. Hindawi 2018-02-12 /pmc/articles/PMC5896335/ /pubmed/29789787 http://dx.doi.org/10.1155/2018/3819719 Text en Copyright © 2018 Wanyan Tan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tan, Wanyan
Wang, Wei
Ma, Qingfeng
Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title_full Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title_fullStr Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title_full_unstemmed Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title_short Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
title_sort physiological and pathological function of serine/arginine-rich splicing factor 4 and related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896335/
https://www.ncbi.nlm.nih.gov/pubmed/29789787
http://dx.doi.org/10.1155/2018/3819719
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