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Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study

OBJECTIVE: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). METHODS: A cross-sectional study of 91 Chinese children and adolescents with ISS was perform...

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Autores principales: Wang, Panpan, Ji, Baolan, Shao, Qian, Zhang, Mei, Ban, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896336/
https://www.ncbi.nlm.nih.gov/pubmed/29789791
http://dx.doi.org/10.1155/2018/4259098
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author Wang, Panpan
Ji, Baolan
Shao, Qian
Zhang, Mei
Ban, Bo
author_facet Wang, Panpan
Ji, Baolan
Shao, Qian
Zhang, Mei
Ban, Bo
author_sort Wang, Panpan
collection PubMed
description OBJECTIVE: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). METHODS: A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated. RESULTS: A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P = 0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β  −0.055, 95% CI −0.081–−0.028; P < 0.001) or more than 301 μmol/L (β  −0.005, 95% CI −0.013–0.002; P = 0.174). CONCLUSIONS: This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
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spelling pubmed-58963362018-05-22 Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study Wang, Panpan Ji, Baolan Shao, Qian Zhang, Mei Ban, Bo Biomed Res Int Research Article OBJECTIVE: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). METHODS: A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated. RESULTS: A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P = 0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β  −0.055, 95% CI −0.081–−0.028; P < 0.001) or more than 301 μmol/L (β  −0.005, 95% CI −0.013–0.002; P = 0.174). CONCLUSIONS: This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect. Hindawi 2018-01-28 /pmc/articles/PMC5896336/ /pubmed/29789791 http://dx.doi.org/10.1155/2018/4259098 Text en Copyright © 2018 Panpan Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Panpan
Ji, Baolan
Shao, Qian
Zhang, Mei
Ban, Bo
Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title_full Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title_fullStr Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title_full_unstemmed Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title_short Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
title_sort association between insulin-like growth factor-1 and uric acid in chinese children and adolescents with idiopathic short stature: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896336/
https://www.ncbi.nlm.nih.gov/pubmed/29789791
http://dx.doi.org/10.1155/2018/4259098
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