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Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors

P2X7 receptor (P2X7R) activation requires ∼100-fold higher concentrations of ATP than other P2X receptor (P2XR) subtypes. Such high levels are found during cellular stress, and P2X7Rs consequently contribute to a range of pathophysiological conditions. We have used chimeric and mutant P2X7Rs, couple...

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Detalles Bibliográficos
Autores principales:	Allsopp, Rebecca C., Dayl, Sudad, Bin Dayel, Anfal, Schmid, Ralf, Evans, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896373/ https://www.ncbi.nlm.nih.gov/pubmed/29535152 http://dx.doi.org/10.1124/mol.117.111021

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