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Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea
PURPOSE: To investigate the clinical features and ocular manifestations of biopsy-proven pulmonary sarcoidosis in Korea. METHODS: 55 patients diagnosed with pulmonary sarcoidosis by bronchoscopic or excisional biopsy were included. By retrospective clinical chart review, we investigated features of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896406/ https://www.ncbi.nlm.nih.gov/pubmed/29785303 http://dx.doi.org/10.1155/2018/9308414 |
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author | Choi, Seung Yong Lee, Jae Hoon Won, Jae-Yon Shin, Jeong Ah Park, Young-Hoon |
author_facet | Choi, Seung Yong Lee, Jae Hoon Won, Jae-Yon Shin, Jeong Ah Park, Young-Hoon |
author_sort | Choi, Seung Yong |
collection | PubMed |
description | PURPOSE: To investigate the clinical features and ocular manifestations of biopsy-proven pulmonary sarcoidosis in Korea. METHODS: 55 patients diagnosed with pulmonary sarcoidosis by bronchoscopic or excisional biopsy were included. By retrospective clinical chart review, we investigated features of uveitis, ocular and systemic treatments, visual acuity, angiotensin-converting enzyme level, chest radiography, and pulmonary function tests. Clinical features were analyzed by presence of uveitis, site of biopsy, and first manifested sign of sarcoidosis. RESULTS: The group with uveitis (n = 39) presented with higher systemic (71.8%) and immunosuppressive treatment rates (35.9%) than the group without uveitis (31.3%, 0%, resp.) (P = 0.007, P = 0.005, resp.). There were no significant differences in clinical features, including systemic treatment rate, by type of biopsy. Of 39 patients with uveitis, the group with ocular manifestation as a first sign of sarcoidosis showed higher systemic and immunosuppressive treatment rates (88.9%, 55.6%) compared to the group with pulmonary manifestation as a first sign (57.1%, 19.0%) (P = 0.037, P = 0.018, resp.). CONCLUSIONS: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. |
format | Online Article Text |
id | pubmed-5896406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58964062018-05-21 Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea Choi, Seung Yong Lee, Jae Hoon Won, Jae-Yon Shin, Jeong Ah Park, Young-Hoon J Ophthalmol Research Article PURPOSE: To investigate the clinical features and ocular manifestations of biopsy-proven pulmonary sarcoidosis in Korea. METHODS: 55 patients diagnosed with pulmonary sarcoidosis by bronchoscopic or excisional biopsy were included. By retrospective clinical chart review, we investigated features of uveitis, ocular and systemic treatments, visual acuity, angiotensin-converting enzyme level, chest radiography, and pulmonary function tests. Clinical features were analyzed by presence of uveitis, site of biopsy, and first manifested sign of sarcoidosis. RESULTS: The group with uveitis (n = 39) presented with higher systemic (71.8%) and immunosuppressive treatment rates (35.9%) than the group without uveitis (31.3%, 0%, resp.) (P = 0.007, P = 0.005, resp.). There were no significant differences in clinical features, including systemic treatment rate, by type of biopsy. Of 39 patients with uveitis, the group with ocular manifestation as a first sign of sarcoidosis showed higher systemic and immunosuppressive treatment rates (88.9%, 55.6%) compared to the group with pulmonary manifestation as a first sign (57.1%, 19.0%) (P = 0.037, P = 0.018, resp.). CONCLUSIONS: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. Hindawi 2018-02-11 /pmc/articles/PMC5896406/ /pubmed/29785303 http://dx.doi.org/10.1155/2018/9308414 Text en Copyright © 2018 Seung Yong Choi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Choi, Seung Yong Lee, Jae Hoon Won, Jae-Yon Shin, Jeong Ah Park, Young-Hoon Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title | Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title_full | Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title_fullStr | Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title_full_unstemmed | Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title_short | Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea |
title_sort | ocular manifestations of biopsy-proven pulmonary sarcoidosis in korea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896406/ https://www.ncbi.nlm.nih.gov/pubmed/29785303 http://dx.doi.org/10.1155/2018/9308414 |
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