Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up

A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epst...

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Autores principales: Jha, Lokesh K., Ulmer, Laura L., Olivera-Martinez, Marco A., McCashland, Timothy M., Fu, Kai, Rochling, Fedja A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896418/
https://www.ncbi.nlm.nih.gov/pubmed/29796326
http://dx.doi.org/10.1155/2018/9324872
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author Jha, Lokesh K.
Ulmer, Laura L.
Olivera-Martinez, Marco A.
McCashland, Timothy M.
Fu, Kai
Rochling, Fedja A.
author_facet Jha, Lokesh K.
Ulmer, Laura L.
Olivera-Martinez, Marco A.
McCashland, Timothy M.
Fu, Kai
Rochling, Fedja A.
author_sort Jha, Lokesh K.
collection PubMed
description A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.
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spelling pubmed-58964182018-05-24 Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up Jha, Lokesh K. Ulmer, Laura L. Olivera-Martinez, Marco A. McCashland, Timothy M. Fu, Kai Rochling, Fedja A. Case Reports Hepatol Case Report A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up. Hindawi 2018-01-28 /pmc/articles/PMC5896418/ /pubmed/29796326 http://dx.doi.org/10.1155/2018/9324872 Text en Copyright © 2018 Lokesh K. Jha et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jha, Lokesh K.
Ulmer, Laura L.
Olivera-Martinez, Marco A.
McCashland, Timothy M.
Fu, Kai
Rochling, Fedja A.
Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_full Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_fullStr Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_full_unstemmed Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_short Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_sort castleman's disease and posttransplant lymphoproliferative disorder after liver transplant: 3-year follow-up
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896418/
https://www.ncbi.nlm.nih.gov/pubmed/29796326
http://dx.doi.org/10.1155/2018/9324872
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