FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become...

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Detalles Bibliográficos
Autores principales: Weber, Michael, Schaer, Jonas, Walther, Grit, Kaerger, Kerstin, Steinmann, Jörg, Rath, Peter-Michael, Spiess, Birgit, Buchheidt, Dieter, Hamprecht, Axel, Kurzai, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896429/
https://www.ncbi.nlm.nih.gov/pubmed/28340175
http://dx.doi.org/10.1093/mmy/myx015
Descripción
Sumario:Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.

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