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FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become...

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Autores principales: Weber, Michael, Schaer, Jonas, Walther, Grit, Kaerger, Kerstin, Steinmann, Jörg, Rath, Peter-Michael, Spiess, Birgit, Buchheidt, Dieter, Hamprecht, Axel, Kurzai, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896429/
https://www.ncbi.nlm.nih.gov/pubmed/28340175
http://dx.doi.org/10.1093/mmy/myx015
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author Weber, Michael
Schaer, Jonas
Walther, Grit
Kaerger, Kerstin
Steinmann, Jörg
Rath, Peter-Michael
Spiess, Birgit
Buchheidt, Dieter
Hamprecht, Axel
Kurzai, Oliver
author_facet Weber, Michael
Schaer, Jonas
Walther, Grit
Kaerger, Kerstin
Steinmann, Jörg
Rath, Peter-Michael
Spiess, Birgit
Buchheidt, Dieter
Hamprecht, Axel
Kurzai, Oliver
author_sort Weber, Michael
collection PubMed
description Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.
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spelling pubmed-58964292018-04-17 FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus Weber, Michael Schaer, Jonas Walther, Grit Kaerger, Kerstin Steinmann, Jörg Rath, Peter-Michael Spiess, Birgit Buchheidt, Dieter Hamprecht, Axel Kurzai, Oliver Med Mycol Brief Report Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus. Oxford University Press 2018-01 2017-03-11 /pmc/articles/PMC5896429/ /pubmed/28340175 http://dx.doi.org/10.1093/mmy/myx015 Text en © The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Weber, Michael
Schaer, Jonas
Walther, Grit
Kaerger, Kerstin
Steinmann, Jörg
Rath, Peter-Michael
Spiess, Birgit
Buchheidt, Dieter
Hamprecht, Axel
Kurzai, Oliver
FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title_full FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title_fullStr FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title_full_unstemmed FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title_short FunResDB—A web resource for genotypic susceptibility testing of Aspergillus fumigatus
title_sort funresdb—a web resource for genotypic susceptibility testing of aspergillus fumigatus
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896429/
https://www.ncbi.nlm.nih.gov/pubmed/28340175
http://dx.doi.org/10.1093/mmy/myx015
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