Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study

The understanding of the dynamical and mechanistic aspects that lie behind siRNA-based gene regulation is a requisite to boost the performance of siRNA therapeutics. A systematic experimental and computational study on the 3′-overhang structural requirements for the design of more specific and poten...

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Detalles Bibliográficos
Autores principales: Alagia, Adele, Jorge, Andreia F., Aviñó, Anna, Cova, Tânia F. G. G., Crehuet, Ramon, Grijalvo, Santiago, Pais, Alberto A. C. C., Eritja, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896489/
https://www.ncbi.nlm.nih.gov/pubmed/29719684
http://dx.doi.org/10.1039/c8sc00010g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896489/
https://www.ncbi.nlm.nih.gov/pubmed/29719684
http://dx.doi.org/10.1039/c8sc00010g

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