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Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis

BACKGROUND: Gambogic acid (GA) is the main active ingredient of resin gamboges and possesses anti-cancer activity toward various human cancer cells. However, clinical application of GA has been limited by its poor aqueous solubility and dose-limiting toxicities. Cell-penetrating peptides (CPPs) are...

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Detalles Bibliográficos
Autores principales:	Lyu, Lei, Huang, Lu-qi, Huang, Tao, Xiang, Wei, Yuan, Jing-dong, Zhang, Chuan-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896666/ https://www.ncbi.nlm.nih.gov/pubmed/29670331 http://dx.doi.org/10.2147/DDDT.S161821

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