Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

We introduce an approach for identifying disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics. Our approach uses stratified LD score regression to test whether disease heritability is enriched in regions surro...

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Detalles Bibliográficos
Autores principales: Finucane, Hilary K., Reshef, Yakir A., Anttila, Verneri, Slowikowski, Kamil, Gusev, Alexander, Byrnes, Andrea, Gazal, Steven, Loh, Po-Ru, Lareau, Caleb, Shoresh, Noam, Genovese, Giulio, Saunders, Arpiar, Macosko, Evan, Pollack, Samuela, Perry, John R.B., Buenrostro, Jason D., Bernstein, Bradley E., Raychaudhuri, Soumya, McCarroll, Steven, Neale, Benjamin M., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896795/
https://www.ncbi.nlm.nih.gov/pubmed/29632380
http://dx.doi.org/10.1038/s41588-018-0081-4

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