Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

HIV has been reported to be cytotoxic in vitro and in lymph node infection models. Using a computational approach, we found that partial inhibition of transmissions of multiple virions per cell could lead to increased numbers of live infected cells. If the number of viral DNA copies remains above on...

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Detalles Bibliográficos
Autores principales: Jackson, Laurelle, Hunter, Jessica, Cele, Sandile, Ferreira, Isabella Markham, Young, Andrew C, Karim, Farina, Madansein, Rajhmun, Dullabh, Kaylesh J, Chen, Chih-Yuan, Buckels, Noel J, Ganga, Yashica, Khan, Khadija, Boulle, Mikael, Lustig, Gila, Neher, Richard A, Sigal, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896883/
https://www.ncbi.nlm.nih.gov/pubmed/29555018
http://dx.doi.org/10.7554/eLife.30134

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