Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

Notch signalling maintains stem cell regeneration at the mouse intestinal crypt base and balances the absorptive and secretory lineages in the upper crypt and villus. Here we report the role of Fringe family of glycosyltransferases in modulating Notch activity in the two compartments. At the crypt b...

Descripción completa

Detalles Bibliográficos
Autores principales: Kadur Lakshminarasimha Murthy, Preetish, Srinivasan, Tara, Bochter, Matthew S, Xi, Rui, Varanko, Anastasia Kristine, Tung, Kuei-Ling, Semerci, Fatih, Xu, Keli, Maletic-Savatic, Mirjana, Cole, Susan E, Shen, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896954/
https://www.ncbi.nlm.nih.gov/pubmed/29629872
http://dx.doi.org/10.7554/eLife.35710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896954/
https://www.ncbi.nlm.nih.gov/pubmed/29629872
http://dx.doi.org/10.7554/eLife.35710

Ejemplares similares