Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping

BACKGROUND: Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Latin America. There is no vaccine and the only drugs have severe side effects. Efforts to generate new therapies are hampered by limitations in our understanding of parasite biology and dise...

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Detalles Bibliográficos
Autores principales: Costa, Fernanda Cristina, Francisco, Amanda Fortes, Jayawardhana, Shiromani, Calderano, Simone Guedes, Lewis, Michael D., Olmo, Francisco, Beneke, Tom, Gluenz, Eva, Sunter, Jack, Dean, Samuel, Kelly, John Morrison, Taylor, Martin Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897030/
https://www.ncbi.nlm.nih.gov/pubmed/29608569
http://dx.doi.org/10.1371/journal.pntd.0006388

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