HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial against idiopathic pulmonary fibrosis. Here we show that O...

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Detalles Bibliográficos
Autores principales: Sevin, Margaux, Kubovcakova, Lucia, Pernet, Nicolas, Causse, Sébastien, Vitte, Franck, Villeval, Jean Luc, Lacout, Catherine, Cordonnier, Marine, Rodrigues-Lima, Fernando, Chanteloup, Gaétan, Mosca, Matthieu, Chrétien, Marie-Lorraine, Bastie, Jean Noël, Audia, Sylvain, Sagot, Paul, Ramla, Selim, Martin, Laurent, Gleave, Martin, Mezger, Valérie, Skoda, Radek, Plo, Isabelle, Garrido, Carmen, Girodon, François, de Thonel, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897330/
https://www.ncbi.nlm.nih.gov/pubmed/29650953
http://dx.doi.org/10.1038/s41467-018-03627-9

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