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Gene expression links functional networks across cortex and striatum
The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular prope...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897339/ https://www.ncbi.nlm.nih.gov/pubmed/29651138 http://dx.doi.org/10.1038/s41467-018-03811-x |
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author | Anderson, Kevin M. Krienen, Fenna M. Choi, Eun Young Reinen, Jenna M. Yeo, B. T. Thomas Holmes, Avram J. |
author_facet | Anderson, Kevin M. Krienen, Fenna M. Choi, Eun Young Reinen, Jenna M. Yeo, B. T. Thomas Holmes, Avram J. |
author_sort | Anderson, Kevin M. |
collection | PubMed |
description | The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in health and disease. |
format | Online Article Text |
id | pubmed-5897339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58973392018-04-16 Gene expression links functional networks across cortex and striatum Anderson, Kevin M. Krienen, Fenna M. Choi, Eun Young Reinen, Jenna M. Yeo, B. T. Thomas Holmes, Avram J. Nat Commun Article The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in health and disease. Nature Publishing Group UK 2018-04-12 /pmc/articles/PMC5897339/ /pubmed/29651138 http://dx.doi.org/10.1038/s41467-018-03811-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Anderson, Kevin M. Krienen, Fenna M. Choi, Eun Young Reinen, Jenna M. Yeo, B. T. Thomas Holmes, Avram J. Gene expression links functional networks across cortex and striatum |
title | Gene expression links functional networks across cortex and striatum |
title_full | Gene expression links functional networks across cortex and striatum |
title_fullStr | Gene expression links functional networks across cortex and striatum |
title_full_unstemmed | Gene expression links functional networks across cortex and striatum |
title_short | Gene expression links functional networks across cortex and striatum |
title_sort | gene expression links functional networks across cortex and striatum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897339/ https://www.ncbi.nlm.nih.gov/pubmed/29651138 http://dx.doi.org/10.1038/s41467-018-03811-x |
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