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Gene expression links functional networks across cortex and striatum

The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular prope...

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Autores principales: Anderson, Kevin M., Krienen, Fenna M., Choi, Eun Young, Reinen, Jenna M., Yeo, B. T. Thomas, Holmes, Avram J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897339/
https://www.ncbi.nlm.nih.gov/pubmed/29651138
http://dx.doi.org/10.1038/s41467-018-03811-x
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author Anderson, Kevin M.
Krienen, Fenna M.
Choi, Eun Young
Reinen, Jenna M.
Yeo, B. T. Thomas
Holmes, Avram J.
author_facet Anderson, Kevin M.
Krienen, Fenna M.
Choi, Eun Young
Reinen, Jenna M.
Yeo, B. T. Thomas
Holmes, Avram J.
author_sort Anderson, Kevin M.
collection PubMed
description The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in health and disease.
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spelling pubmed-58973392018-04-16 Gene expression links functional networks across cortex and striatum Anderson, Kevin M. Krienen, Fenna M. Choi, Eun Young Reinen, Jenna M. Yeo, B. T. Thomas Holmes, Avram J. Nat Commun Article The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in health and disease. Nature Publishing Group UK 2018-04-12 /pmc/articles/PMC5897339/ /pubmed/29651138 http://dx.doi.org/10.1038/s41467-018-03811-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Anderson, Kevin M.
Krienen, Fenna M.
Choi, Eun Young
Reinen, Jenna M.
Yeo, B. T. Thomas
Holmes, Avram J.
Gene expression links functional networks across cortex and striatum
title Gene expression links functional networks across cortex and striatum
title_full Gene expression links functional networks across cortex and striatum
title_fullStr Gene expression links functional networks across cortex and striatum
title_full_unstemmed Gene expression links functional networks across cortex and striatum
title_short Gene expression links functional networks across cortex and striatum
title_sort gene expression links functional networks across cortex and striatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897339/
https://www.ncbi.nlm.nih.gov/pubmed/29651138
http://dx.doi.org/10.1038/s41467-018-03811-x
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