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Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models

In addition to their canonical roles in regulating cell cycle transition and transcription, cyclin-dependent kinases (CDKs) have been shown to coordinate DNA damage response pathways, suggesting a rational pairing of CDK inhibitors with genotoxic chemotherapeutic agents in the treatment of human mal...

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Detalles Bibliográficos
Autores principales:	Syn, Nicholas L., Lim, Pei Li, Kong, Li Ren, Wang, Lingzhi, Wong, Andrea Li-Ann, Lim, Chwee Ming, Loh, Thomas Kwok Seng, Siemeister, Gerhard, Goh, Boon Cher, Hsieh, Wen-Son
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897350/ https://www.ncbi.nlm.nih.gov/pubmed/29666673 http://dx.doi.org/10.1038/s41392-018-0010-0

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