Cargando…

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

Autophagy is a critical regulator of cellular homeostasis, dysregulation of which is associated with diverse diseases. Here we show therapeutic effects of a novel autophagy enhancer identified by high-throughput screening of a chemical library against metabolic syndrome. An autophagy enhancer increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Hyejin, Lim, Yu-Mi, Kim, Kook Hwan, Jeon, Young Eui, Park, Kihyoun, Kim, Jinyoung, Hwang, Hui-Yun, Lee, Dong Jin, Pagire, Haushabhau, Kwon, Ho Jeong, Ahn, Jin Hee, Lee, Myung-Shik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897400/ https://www.ncbi.nlm.nih.gov/pubmed/29650965 http://dx.doi.org/10.1038/s41467-018-03939-w

Ejemplares similares

β-cell autophagy: Mechanism and role in β-cell dysfunction
por: Lee, Yong-ho, et al.
Publicado: (2019)

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
por: Kim, Jinyoung, et al.
Publicado: (2021)

Dopamine neuron induction and the neuroprotective effects of thyroid hormone derivatives
por: Lee, Eun-Hye, et al.
Publicado: (2019)

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4(+) T Cells Ameliorates Intestinal Inflammation
por: Lee, Hoyul, et al.
Publicado: (2022)

Current Status of Autophagy Enhancers in Metabolic Disorders and Other Diseases
por: Park, Kihyoun, et al.
Publicado: (2022)

The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes
por: Kim, Jinyoung, et al.
Publicado: (2018)

Lysosomal Ca(2+)-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress
por: Park, Kihyoun, et al.
Publicado: (2022)

Amelioration of obesity-induced diabetes by a novel autophagy enhancer
por: Lim, Hyejin, et al.
Publicado: (2018)

Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease
por: Pagire, Suvarna H., et al.
Publicado: (2022)

Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
por: Kim, Jinyoung, et al.
Publicado: (2022)

ENOblock inhibits the pathology of diet-induced obesity
por: Cho, Haaglim, et al.
Publicado: (2019)

Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis
por: Lee, June-Chul, et al.
Publicado: (2017)

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells
por: Quan, Wenying, et al.
Publicado: (2012)

Pancreatic β-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal Ca(2+) release
por: Oh, Soo-Jin, et al.
Publicado: (2023)

Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia
por: Kim, Wan-Young, et al.
Publicado: (2019)

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
por: Kim, Kook Hwan, et al.
Publicado: (2014)

Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
por: Kim, Kook Hwan, et al.
Publicado: (2018)

Role of Autophagy in the Pathogenesis of Diabetes and Therapeutic Potential of Autophagy Modulators in the Treatment of Diabetes and Metabolic Syndrome
por: Oh, Soo-Jin, et al.
Publicado: (2022)

General Anesthetic Agents and Renal Function after Nephrectomy
por: Lee, Ho-Jin, et al.
Publicado: (2019)

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
por: Nam, Sun Ah, et al.
Publicado: (2019)

Overview of the Minireviews on Autophagy
por: Lee, Myung-Shik
Publicado: (2018)

Folate Receptor Targeted Imaging Using Poly (ethylene glycol)-folate: In Vitro and In Vivo Studies
por: Kim, Se-Lim, et al.
Publicado: (2007)

Stimulation of Toll-Like Receptor 3 Diminishes Intracellular Growth of Salmonella Typhimurium by Enhancing Autophagy in Murine Macrophages
por: Lee, Hyo-Ji, et al.
Publicado: (2021)

Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells
por: Han, Jang Hee, et al.
Publicado: (2022)

Role and mechanism of pancreatic β‐cell death in diabetes: The emerging role of autophagy
por: Kim, Kyoung‐Ah, et al.
Publicado: (2010)

Role of Autophagy in the Control of Cell Death and Inflammation
por: Lee, Myung-Shik
Publicado: (2009)

Automatic stridor detection using small training set via patch-wise few-shot learning for diagnosis of multiple system atrophy
por: Ahn, Jong Hyeon, et al.
Publicado: (2023)

Effects of epicatechin, a crosslinking agent, on human dental pulp cells cultured in collagen scaffolds
por: Lim, Eun-su, et al.
Publicado: (2016)

Role of Autophagy in the Control of Body Metabolism
por: Quan, Wenying, et al.
Publicado: (2013)

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity
por: Jeon, Hyejin, et al.
Publicado: (2012)

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
por: Lee, Jinjoo, et al.
Publicado: (2020)

The care cascade for hepatitis C virus and prognosis of chronic hepatitis C patients treated with antiviral agents in a tertiary hospital
por: Yoo, Sung Hwan, et al.
Publicado: (2023)

P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation
por: Lim, Yongwoon, et al.
Publicado: (2021)

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
por: Kim, Kook Hwan, et al.
Publicado: (2013)

Pharmacology of Intracisternal or Intrathecal Glycine, Muscimol, and Baclofen in Strychnine-induced Thermal Hyperalgesia of Mice
por: Lee, Il Ok, et al.
Publicado: (2011)

Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
por: Lee, Sung Woo, et al.
Publicado: (2017)

The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice
por: Shin, Hyejin, et al.
Publicado: (2017)

Improvement in Erythropoieis-stimulating Agent-induced Pure Red-cell Aplasia by Introduction of Darbepoetin-α When the Anti-erythropoietin Antibody Titer Declines Spontaneously
por: Lee, Hajeong, et al.
Publicado: (2010)

Transcription Factor TonEBP Stimulates Hyperosmolality-Dependent Arginine Vasopressin Gene Expression in the Mouse Hypothalamus
por: Kim, Dong Hee, et al.
Publicado: (2021)

Size Control of (99m)Tc-tin Colloid Using PVP and Buffer Solution for Sentinel Lymph Node Detection
por: Kim, Eun-Mi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_brqe1ktaovknt4svnb35et66tn