Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequence...

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Detalles Bibliográficos
Autores principales: Hirose, Misa, Schilf, Paul, Gupta, Yask, Zarse, Kim, Künstner, Axel, Fähnrich, Anke, Busch, Hauke, Yin, Junping, Wright, Marvin N., Ziegler, Andreas, Vallier, Marie, Belheouane, Meriem, Baines, John F, Tautz, Diethard, Johann, Kornelia, Oelkrug, Rebecca, Mittag, Jens, Lehnert, Hendrik, Othman, Alaa, Jöhren, Olaf, Schwaninger, Markus, Prehn, Cornelia, Adamski, Jerzy, Shima, Kensuke, Rupp, Jan, Häsler, Robert, Fuellen, Georg, Köhling, Rüdiger, Ristow, Michael, Ibrahim, Saleh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897405/
https://www.ncbi.nlm.nih.gov/pubmed/29651131
http://dx.doi.org/10.1038/s41598-018-24290-6

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