The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane

Kv1.3 channels are expressed in several cell types including immune cells, such as T lymphocytes. The targeting of Kv1.3 to the plasma membrane is essential for T cell clonal expansion and assumed to be guided by the C-terminus of the channel. Using two point mutants of Kv1.3 with remarkably differe...

Descripción completa

Detalles Bibliográficos
Autores principales: Voros, Orsolya, Szilagyi, Orsolya, Balajthy, András, Somodi, Sándor, Panyi, Gyorgy, Hajdu, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897520/
https://www.ncbi.nlm.nih.gov/pubmed/29650988
http://dx.doi.org/10.1038/s41598-018-24159-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897520/
https://www.ncbi.nlm.nih.gov/pubmed/29650988
http://dx.doi.org/10.1038/s41598-018-24159-8

Ejemplares similares