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Overview on Clinical Relevance of Intra-Tumor Heterogeneity
Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897590/ https://www.ncbi.nlm.nih.gov/pubmed/29682505 http://dx.doi.org/10.3389/fmed.2018.00085 |
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author | Stanta, Giorgio Bonin, Serena |
author_facet | Stanta, Giorgio Bonin, Serena |
author_sort | Stanta, Giorgio |
collection | PubMed |
description | Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spatial and temporal phenomena, which are often peculiar for every single patient. This review tries to describe all the types of ITH including morphohistological ITH, and at the molecular level clonal ITH derived from genomic instability and nonclonal ITH derived from microenvironment interaction. It is important to consider the different types of ITH as a whole for any patient to investigate on cancer progression, prognosis, and treatment opportunities. From a practical point of view, analytical methods that are widely accessible today, or will be in the near future, are evaluated to investigate the complex pattern of ITH in a reproducible way for a clinical application. |
format | Online Article Text |
id | pubmed-5897590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58975902018-04-20 Overview on Clinical Relevance of Intra-Tumor Heterogeneity Stanta, Giorgio Bonin, Serena Front Med (Lausanne) Medicine Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spatial and temporal phenomena, which are often peculiar for every single patient. This review tries to describe all the types of ITH including morphohistological ITH, and at the molecular level clonal ITH derived from genomic instability and nonclonal ITH derived from microenvironment interaction. It is important to consider the different types of ITH as a whole for any patient to investigate on cancer progression, prognosis, and treatment opportunities. From a practical point of view, analytical methods that are widely accessible today, or will be in the near future, are evaluated to investigate the complex pattern of ITH in a reproducible way for a clinical application. Frontiers Media S.A. 2018-04-06 /pmc/articles/PMC5897590/ /pubmed/29682505 http://dx.doi.org/10.3389/fmed.2018.00085 Text en Copyright © 2018 Stanta and Bonin. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Stanta, Giorgio Bonin, Serena Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title | Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title_full | Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title_fullStr | Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title_full_unstemmed | Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title_short | Overview on Clinical Relevance of Intra-Tumor Heterogeneity |
title_sort | overview on clinical relevance of intra-tumor heterogeneity |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897590/ https://www.ncbi.nlm.nih.gov/pubmed/29682505 http://dx.doi.org/10.3389/fmed.2018.00085 |
work_keys_str_mv | AT stantagiorgio overviewonclinicalrelevanceofintratumorheterogeneity AT boninserena overviewonclinicalrelevanceofintratumorheterogeneity |