Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in neurulation. Spinal neurulation involves rostral-to-caud...

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Detalles Bibliográficos
Autores principales: Galea, Gabriel L., Nychyk, Oleksandr, Mole, Matteo A., Moulding, Dale, Savery, Dawn, Nikolopoulou, Evanthia, Henderson, Deborah J., Greene, Nicholas D. E., Copp, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897727/
https://www.ncbi.nlm.nih.gov/pubmed/29590636
http://dx.doi.org/10.1242/dmm.032219

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