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Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification
‘Hidden hunger’ involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897740/ https://www.ncbi.nlm.nih.gov/pubmed/29681913 http://dx.doi.org/10.3389/fpls.2018.00443 |
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author | Strobbe, Simon Van Der Straeten, Dominique |
author_facet | Strobbe, Simon Van Der Straeten, Dominique |
author_sort | Strobbe, Simon |
collection | PubMed |
description | ‘Hidden hunger’ involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main dietary component for large population groups, deliver inadequate amounts of micronutrients. Biofortification, the augmentation of natural micronutrient levels in crop products through breeding or genetic engineering, is a pivotal tool in the fight against micronutrient malnutrition (MNM). Although these approaches have shown to be successful in several species, a more extensive knowledge of plant metabolism and function of these micronutrients is required to refine and improve biofortification strategies. This review focuses on the relevant B-vitamins (B1, B6, and B9). First, the role of these vitamins in plant physiology is elaborated, as well their biosynthesis. Second, the rationale behind vitamin biofortification is illustrated in view of pathophysiology and epidemiology of the deficiency. Furthermore, advances in biofortification, via metabolic engineering or breeding, are presented. Finally, considerations on B-vitamin multi-biofortified crops are raised, comprising the possible interplay of these vitamins in planta. |
format | Online Article Text |
id | pubmed-5897740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58977402018-04-20 Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification Strobbe, Simon Van Der Straeten, Dominique Front Plant Sci Plant Science ‘Hidden hunger’ involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main dietary component for large population groups, deliver inadequate amounts of micronutrients. Biofortification, the augmentation of natural micronutrient levels in crop products through breeding or genetic engineering, is a pivotal tool in the fight against micronutrient malnutrition (MNM). Although these approaches have shown to be successful in several species, a more extensive knowledge of plant metabolism and function of these micronutrients is required to refine and improve biofortification strategies. This review focuses on the relevant B-vitamins (B1, B6, and B9). First, the role of these vitamins in plant physiology is elaborated, as well their biosynthesis. Second, the rationale behind vitamin biofortification is illustrated in view of pathophysiology and epidemiology of the deficiency. Furthermore, advances in biofortification, via metabolic engineering or breeding, are presented. Finally, considerations on B-vitamin multi-biofortified crops are raised, comprising the possible interplay of these vitamins in planta. Frontiers Media S.A. 2018-04-06 /pmc/articles/PMC5897740/ /pubmed/29681913 http://dx.doi.org/10.3389/fpls.2018.00443 Text en Copyright © 2018 Strobbe and Van Der Straeten. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Strobbe, Simon Van Der Straeten, Dominique Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title | Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title_full | Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title_fullStr | Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title_full_unstemmed | Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title_short | Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification |
title_sort | toward eradication of b-vitamin deficiencies: considerations for crop biofortification |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897740/ https://www.ncbi.nlm.nih.gov/pubmed/29681913 http://dx.doi.org/10.3389/fpls.2018.00443 |
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