Cargando…

Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids

The New Delhi metallo-β-lactamase (NDM-1) is an important clinical target for antimicrobial research, but there are insufficient clinically useful inhibitors and the details of NDM-1 enzyme catalysis remain unclear. The aim of this work is to provide a thermodynamic profile of NDM-1 catalysed hydrol...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qian, He, Yuan, Lu, Rui, Wang, Wen-Ming, Yang, Ke-Wu, Fan, Hai Ming, Jin, Yi, Blackburn, G. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897741/
https://www.ncbi.nlm.nih.gov/pubmed/29507059
http://dx.doi.org/10.1042/BSR20180244