Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins....

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Detalles Bibliográficos
Autores principales: Dandela, Rambabu, Mantin, Danielle, Cravatt, Benjamin F., Rayo, Josep, Meijler, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897874/
https://www.ncbi.nlm.nih.gov/pubmed/29719702
http://dx.doi.org/10.1039/c7sc04287f
Descripción
Sumario:The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

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