Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins....

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Detalles Bibliográficos
Autores principales: Dandela, Rambabu, Mantin, Danielle, Cravatt, Benjamin F., Rayo, Josep, Meijler, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897874/
https://www.ncbi.nlm.nih.gov/pubmed/29719702
http://dx.doi.org/10.1039/c7sc04287f
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author Dandela, Rambabu
Mantin, Danielle
Cravatt, Benjamin F.
Rayo, Josep
Meijler, Michael M.
author_facet Dandela, Rambabu
Mantin, Danielle
Cravatt, Benjamin F.
Rayo, Josep
Meijler, Michael M.
author_sort Dandela, Rambabu
collection PubMed
description The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.
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spelling pubmed-58978742018-05-01 Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa Dandela, Rambabu Mantin, Danielle Cravatt, Benjamin F. Rayo, Josep Meijler, Michael M. Chem Sci Chemistry The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections. Royal Society of Chemistry 2018-01-19 /pmc/articles/PMC5897874/ /pubmed/29719702 http://dx.doi.org/10.1039/c7sc04287f Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Dandela, Rambabu
Mantin, Danielle
Cravatt, Benjamin F.
Rayo, Josep
Meijler, Michael M.
Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title_full Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title_fullStr Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title_full_unstemmed Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title_short Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
title_sort proteome-wide mapping of pqs-interacting proteins in pseudomonas aeruginosa
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897874/
https://www.ncbi.nlm.nih.gov/pubmed/29719702
http://dx.doi.org/10.1039/c7sc04287f
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