Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

BACKGROUND: Multidrug resistance-associated protein 1 (MRP1) overexpression plays a major role in chemoresistance in glioblastoma multiforme (GBM) contributing to its notorious deadly nature. Although MRP1-siRNA transfection to GBM in vitro has been shown to sensitise the cells to drug, MRP1 silenci...

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Detalles Bibliográficos
Autores principales: Tong, Wing Yin, Alnakhli, Mohammed, Bhardwaj, Richa, Apostolou, Sinoula, Sinha, Sougata, Fraser, Cara, Kuchel, Tim, Kuss, Bryone, Voelcker, Nicolas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898074/
https://www.ncbi.nlm.nih.gov/pubmed/29653579
http://dx.doi.org/10.1186/s12951-018-0365-y

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