Cargando…

Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review

BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored t...

Descripción completa

Detalles Bibliográficos
Autores principales: Catchlove, Sarah J., Pipingas, Andrew, Hughes, Matthew E., Macpherson, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898077/
https://www.ncbi.nlm.nih.gov/pubmed/29649969
http://dx.doi.org/10.1186/s12868-018-0421-4
_version_ 1783314067928121344
author Catchlove, Sarah J.
Pipingas, Andrew
Hughes, Matthew E.
Macpherson, Helen
author_facet Catchlove, Sarah J.
Pipingas, Andrew
Hughes, Matthew E.
Macpherson, Helen
author_sort Catchlove, Sarah J.
collection PubMed
description BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored the relationship between CVR and cognition; here we systematically review this work. RESULTS: We extracted information pertaining to: (1) study location and design, participant characteristics, sample sizes, (2) design of vascular challenge, end-tidal CO(2) (etCO(2)) concentrations (if applicable), (3) MRI protocol, (4) cognitive assessment, (5) CVR values, and outcomes of statistical analyses with cognitive tests. Five studies assessed participants with cognitive impairment compared to controls, one studied patients with multiple sclerosis with or without cognitive impairment compared to controls, one examined patients with moyamoya disease with or without cognitive impairment, two investigated patients with Type 2 diabetes mellitus (T2DM), and one was a cross-sectional study with younger and older healthy adults. Cognition was typically probed using the MMSE and tests of executive function, while a number of vasodilatory techniques were employed. CONCLUSION: CVR was associated with cognition in six of ten studies, but heterogeneity of study samples, designs and vasodilatory methods may have a role in the inconsistent findings. We make recommendations for future research that includes use of a multi-domain cognitive assessment and standardised hypercapnic challenge with MRI.
format Online
Article
Text
id pubmed-5898077
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58980772018-04-20 Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review Catchlove, Sarah J. Pipingas, Andrew Hughes, Matthew E. Macpherson, Helen BMC Neurosci Research Article BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored the relationship between CVR and cognition; here we systematically review this work. RESULTS: We extracted information pertaining to: (1) study location and design, participant characteristics, sample sizes, (2) design of vascular challenge, end-tidal CO(2) (etCO(2)) concentrations (if applicable), (3) MRI protocol, (4) cognitive assessment, (5) CVR values, and outcomes of statistical analyses with cognitive tests. Five studies assessed participants with cognitive impairment compared to controls, one studied patients with multiple sclerosis with or without cognitive impairment compared to controls, one examined patients with moyamoya disease with or without cognitive impairment, two investigated patients with Type 2 diabetes mellitus (T2DM), and one was a cross-sectional study with younger and older healthy adults. Cognition was typically probed using the MMSE and tests of executive function, while a number of vasodilatory techniques were employed. CONCLUSION: CVR was associated with cognition in six of ten studies, but heterogeneity of study samples, designs and vasodilatory methods may have a role in the inconsistent findings. We make recommendations for future research that includes use of a multi-domain cognitive assessment and standardised hypercapnic challenge with MRI. BioMed Central 2018-04-12 /pmc/articles/PMC5898077/ /pubmed/29649969 http://dx.doi.org/10.1186/s12868-018-0421-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Catchlove, Sarah J.
Pipingas, Andrew
Hughes, Matthew E.
Macpherson, Helen
Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title_full Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title_fullStr Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title_full_unstemmed Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title_short Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
title_sort magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898077/
https://www.ncbi.nlm.nih.gov/pubmed/29649969
http://dx.doi.org/10.1186/s12868-018-0421-4
work_keys_str_mv AT catchlovesarahj magneticresonanceimagingforassessmentofcerebrovascularreactivityanditsrelationshiptocognitionasystematicreview
AT pipingasandrew magneticresonanceimagingforassessmentofcerebrovascularreactivityanditsrelationshiptocognitionasystematicreview
AT hughesmatthewe magneticresonanceimagingforassessmentofcerebrovascularreactivityanditsrelationshiptocognitionasystematicreview
AT macphersonhelen magneticresonanceimagingforassessmentofcerebrovascularreactivityanditsrelationshiptocognitionasystematicreview