Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the po...

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Autores principales: Bermudez, Adriana, Alba, Martha P., Vanegas, Magnolia, Patarroyo, Manuel A., Patarroyo, Manuel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898157/
https://www.ncbi.nlm.nih.gov/pubmed/29682500
http://dx.doi.org/10.3389/fchem.2018.00106
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author Bermudez, Adriana
Alba, Martha P.
Vanegas, Magnolia
Patarroyo, Manuel A.
Patarroyo, Manuel E.
author_facet Bermudez, Adriana
Alba, Martha P.
Vanegas, Magnolia
Patarroyo, Manuel A.
Patarroyo, Manuel E.
author_sort Bermudez, Adriana
collection PubMed
description The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ(*) allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.
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spelling pubmed-58981572018-04-20 Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components Bermudez, Adriana Alba, Martha P. Vanegas, Magnolia Patarroyo, Manuel A. Patarroyo, Manuel E. Front Chem Chemistry The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ(*) allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. Frontiers Media S.A. 2018-04-06 /pmc/articles/PMC5898157/ /pubmed/29682500 http://dx.doi.org/10.3389/fchem.2018.00106 Text en Copyright © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Bermudez, Adriana
Alba, Martha P.
Vanegas, Magnolia
Patarroyo, Manuel A.
Patarroyo, Manuel E.
Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title_full Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title_fullStr Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title_full_unstemmed Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title_short Specific β-Turns Precede PPII(L) Structures Binding to Allele-Specific HLA-DRβ1(*) PBRs in Fully-Protective Malaria Vaccine Components
title_sort specific β-turns precede ppii(l) structures binding to allele-specific hla-drβ1(*) pbrs in fully-protective malaria vaccine components
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898157/
https://www.ncbi.nlm.nih.gov/pubmed/29682500
http://dx.doi.org/10.3389/fchem.2018.00106
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