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Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study

INTRODUCTION: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation. METHODS: A new Dose Limiting Toxicity definition was used. The concept of Target Ceiling Dose was...

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Detalles Bibliográficos
Autores principales:	Medioni, Jacques, Brizard, Mara, Elaidi, Reza, Reid, Paul F., Benlhassan, Khadija, Bray, Dorothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898525/ https://www.ncbi.nlm.nih.gov/pubmed/29696184 http://dx.doi.org/10.1016/j.conctc.2017.07.008

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