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Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study
PURPOSE: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. METHODS: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at leas...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898584/ https://www.ncbi.nlm.nih.gov/pubmed/29670328 http://dx.doi.org/10.2147/OPTH.S162203 |
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author | McDonald, Marguerite B Sheha, Hosam Tighe, Sean Janik, Susan B Bowden, Frank W Chokshi, Amit R Singer, Michael A Nanda, Seema Qazi, Mujtaba A Dierker, Damon Shupe, Adam T McMurren, Brittany J |
author_facet | McDonald, Marguerite B Sheha, Hosam Tighe, Sean Janik, Susan B Bowden, Frank W Chokshi, Amit R Singer, Michael A Nanda, Seema Qazi, Mujtaba A Dierker, Damon Shupe, Adam T McMurren, Brittany J |
author_sort | McDonald, Marguerite B |
collection | PubMed |
description | PURPOSE: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. METHODS: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications. The primary outcome was the change in dry eye workshop (DEWS) score after treatment. RESULTS: A total of 97 eyes of 84 patients exhibited severe dry eye despite maximal medical treatments including topical artificial tears, cyclosporine-A, serum, antibiotics, and steroids. Patients manifested with superficial punctate keratitis (86%), filamentary keratitis (13%), exposure keratitis (19%), neurotrophic keratitis (2%), and corneal epithelial defect (7%). After CAM treatment for 5.4±2.8 days, 74 (88%) patients demonstrated an improved ocular surface along with a notable reduction of the severity as the overall DEWS score was significantly reduced from 3.25±0.5 at baseline to 1.44±0.6 at 1 week, 1.45±0.6 at 1 month, and 1.47±0.6 at 3 months (p<0.001). Ten eyes (10%) required repeated treatment to complete healing. Apart from discomfort during CAM placement, there were no adverse events. CONCLUSION: Placement of CAM is promising to enhance the recovery of ocular surface health and reduce signs and symptoms in patients with moderate-to-severe DED. |
format | Online Article Text |
id | pubmed-5898584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58985842018-04-18 Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study McDonald, Marguerite B Sheha, Hosam Tighe, Sean Janik, Susan B Bowden, Frank W Chokshi, Amit R Singer, Michael A Nanda, Seema Qazi, Mujtaba A Dierker, Damon Shupe, Adam T McMurren, Brittany J Clin Ophthalmol Original Research PURPOSE: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. METHODS: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications. The primary outcome was the change in dry eye workshop (DEWS) score after treatment. RESULTS: A total of 97 eyes of 84 patients exhibited severe dry eye despite maximal medical treatments including topical artificial tears, cyclosporine-A, serum, antibiotics, and steroids. Patients manifested with superficial punctate keratitis (86%), filamentary keratitis (13%), exposure keratitis (19%), neurotrophic keratitis (2%), and corneal epithelial defect (7%). After CAM treatment for 5.4±2.8 days, 74 (88%) patients demonstrated an improved ocular surface along with a notable reduction of the severity as the overall DEWS score was significantly reduced from 3.25±0.5 at baseline to 1.44±0.6 at 1 week, 1.45±0.6 at 1 month, and 1.47±0.6 at 3 months (p<0.001). Ten eyes (10%) required repeated treatment to complete healing. Apart from discomfort during CAM placement, there were no adverse events. CONCLUSION: Placement of CAM is promising to enhance the recovery of ocular surface health and reduce signs and symptoms in patients with moderate-to-severe DED. Dove Medical Press 2018-04-09 /pmc/articles/PMC5898584/ /pubmed/29670328 http://dx.doi.org/10.2147/OPTH.S162203 Text en © 2018 McDonald et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research McDonald, Marguerite B Sheha, Hosam Tighe, Sean Janik, Susan B Bowden, Frank W Chokshi, Amit R Singer, Michael A Nanda, Seema Qazi, Mujtaba A Dierker, Damon Shupe, Adam T McMurren, Brittany J Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title | Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title_full | Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title_fullStr | Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title_full_unstemmed | Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title_short | Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study |
title_sort | treatment outcomes in the dry eye amniotic membrane (dream) study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898584/ https://www.ncbi.nlm.nih.gov/pubmed/29670328 http://dx.doi.org/10.2147/OPTH.S162203 |
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