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Sustained analgesic effect of clonidine co-polymer depot in a porcine incisional pain model
BACKGROUND: Previous research suggests that the α(2) adrenergic agonist clonidine, a centrally acting analgesic and antihypertensive, may also have direct effects on peripheral pain generators. However, aqueous injections are limited by rapid systemic absorption leading to off target effects and a b...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898591/ https://www.ncbi.nlm.nih.gov/pubmed/29670396 http://dx.doi.org/10.2147/JPR.S157018 |