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Polymorphisms of Antioxidant Genes as a Target for Diabetes Management
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898637/ https://www.ncbi.nlm.nih.gov/pubmed/29682485 http://dx.doi.org/10.22088/acadpub.BUMS.6.3.135 |
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author | Tabatabaei-Malazy, Ozra Khodaeian, Mehrnoosh Bitarafan, Fatemeh Larijani, Bagher M.Amoli, Mahsa |
author_facet | Tabatabaei-Malazy, Ozra Khodaeian, Mehrnoosh Bitarafan, Fatemeh Larijani, Bagher M.Amoli, Mahsa |
author_sort | Tabatabaei-Malazy, Ozra |
collection | PubMed |
description | Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways. In the development of type 2 DM (T2DM) and its complications, genetic and environmental factors play important roles. Therefore, the aim of this review was to focus on the assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, nitric oxide synthase, and NAD(P)H oxidase and their association with T2DM. The results would be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of DM. |
format | Online Article Text |
id | pubmed-5898637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-58986372018-04-20 Polymorphisms of Antioxidant Genes as a Target for Diabetes Management Tabatabaei-Malazy, Ozra Khodaeian, Mehrnoosh Bitarafan, Fatemeh Larijani, Bagher M.Amoli, Mahsa Int J Mol Cell Med Review Article Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways. In the development of type 2 DM (T2DM) and its complications, genetic and environmental factors play important roles. Therefore, the aim of this review was to focus on the assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, nitric oxide synthase, and NAD(P)H oxidase and their association with T2DM. The results would be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of DM. Babol University of Medical Sciences 2017 2017-08-14 /pmc/articles/PMC5898637/ /pubmed/29682485 http://dx.doi.org/10.22088/acadpub.BUMS.6.3.135 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tabatabaei-Malazy, Ozra Khodaeian, Mehrnoosh Bitarafan, Fatemeh Larijani, Bagher M.Amoli, Mahsa Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title | Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title_full | Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title_fullStr | Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title_full_unstemmed | Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title_short | Polymorphisms of Antioxidant Genes as a Target for Diabetes Management |
title_sort | polymorphisms of antioxidant genes as a target for diabetes management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898637/ https://www.ncbi.nlm.nih.gov/pubmed/29682485 http://dx.doi.org/10.22088/acadpub.BUMS.6.3.135 |
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