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The Neuroprotective Effects of Thymoquinone: A Review

Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacologica...

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Autores principales: Farkhondeh, Tahereh, Samarghandian, Saeed, Shahri, Ali Mohammad Pourbagher, Samini, Fariborz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898665/
https://www.ncbi.nlm.nih.gov/pubmed/29662431
http://dx.doi.org/10.1177/1559325818761455
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author Farkhondeh, Tahereh
Samarghandian, Saeed
Shahri, Ali Mohammad Pourbagher
Samini, Fariborz
author_facet Farkhondeh, Tahereh
Samarghandian, Saeed
Shahri, Ali Mohammad Pourbagher
Samini, Fariborz
author_sort Farkhondeh, Tahereh
collection PubMed
description Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects.
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spelling pubmed-58986652018-04-16 The Neuroprotective Effects of Thymoquinone: A Review Farkhondeh, Tahereh Samarghandian, Saeed Shahri, Ali Mohammad Pourbagher Samini, Fariborz Dose Response Commentary Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects. SAGE Publications 2018-04-11 /pmc/articles/PMC5898665/ /pubmed/29662431 http://dx.doi.org/10.1177/1559325818761455 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Farkhondeh, Tahereh
Samarghandian, Saeed
Shahri, Ali Mohammad Pourbagher
Samini, Fariborz
The Neuroprotective Effects of Thymoquinone: A Review
title The Neuroprotective Effects of Thymoquinone: A Review
title_full The Neuroprotective Effects of Thymoquinone: A Review
title_fullStr The Neuroprotective Effects of Thymoquinone: A Review
title_full_unstemmed The Neuroprotective Effects of Thymoquinone: A Review
title_short The Neuroprotective Effects of Thymoquinone: A Review
title_sort neuroprotective effects of thymoquinone: a review
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898665/
https://www.ncbi.nlm.nih.gov/pubmed/29662431
http://dx.doi.org/10.1177/1559325818761455
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