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Piperazinyl fragment improves anticancer activity of Triapine

A new class of TSCs containing piperazine (piperazinylogs) of Triapine, was designed to fulfill the di-substitution pattern at the TSCs N4 position, which is a crucial prerequisite for the high activity of the previously obtained TSC compounds–DpC and Dp44mT. We tested the important physicochemical...

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Detalles Bibliográficos
Autores principales:	Rejmund, Marta, Mrozek-Wilczkiewicz, Anna, Malarz, Katarzyna, Pyrkosz-Bulska, Monika, Gajcy, Kamila, Sajewicz, Mieczyslaw, Musiol, Robert, Polanski, Jaroslaw
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898707/ https://www.ncbi.nlm.nih.gov/pubmed/29652894 http://dx.doi.org/10.1371/journal.pone.0188767

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