Cargando…

Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation

There is evidence that dendritic cells (DCs) undergo age-related changes that modulate their function with their key role being priming antigen-specific effector T cells. This occurs once DCs develop into antigen-presenting cells in response to stimuli/danger signals. However, the effects of aging o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gardner, Joanne K., Cornwall, Scott M. J., Musk, Arthur W., Alvarez, John, Mamotte, Cyril D. S., Jackaman, Connie, Nowak, Anna K., Nelson, Delia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898732/ https://www.ncbi.nlm.nih.gov/pubmed/29652910 http://dx.doi.org/10.1371/journal.pone.0195313

Ejemplares similares

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy
por: Gardner, Joanne K., et al.
Publicado: (2018)

Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function
por: Gardner, Joanne K., et al.
Publicado: (2015)

Lipid-laden partially-activated plasmacytoid and CD4(−)CD8α(+) dendritic cells accumulate in tissues in elderly mice
por: Gardner, Joanne K, et al.
Publicado: (2014)

Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist
por: Young, D. F., et al.
Publicado: (2009)

Nfkb1 Inhibits LPS-Induced IFN-β and IL-12 p40 Production in Macrophages by Distinct Mechanisms
por: Zhao, Xixing, et al.
Publicado: (2012)

Aging Leads to Increased Monocytes and Macrophages With Altered CSF-1 Receptor Expression and Earlier Tumor-Associated Macrophage Expansion in Murine Mesothelioma
por: Duong, Lelinh, et al.
Publicado: (2022)

The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels
por: Portillo, Jose-Andres C., et al.
Publicado: (2010)

Plasmacytoid Dendritic Cells Respond Directly to Apoptotic Cells by Secreting Immune Regulatory IL-10 or IFN-α
por: Simpson, Joanne, et al.
Publicado: (2016)

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
por: Sheikh, Faruk, et al.
Publicado: (2014)

Different Polyubiquitinated Bodies in Human Dendritic Cells: IL-4 Causes PaCS During Differentiation while LPS or IFNα Induces DALIS During Maturation
por: Montagna, Daniela, et al.
Publicado: (2017)

TLR Tolerance Reduces IFN-Alpha Production Despite Plasmacytoid Dendritic Cell Expansion and Anti-Nuclear Antibodies in NZB Bicongenic Mice
por: Pau, Evelyn, et al.
Publicado: (2012)

RNA-Seq transcriptomic profiling of primary murine microglia treated with LPS or LPS + IFNγ
por: Pulido-Salgado, Marta, et al.
Publicado: (2018)

Rapid Copper Acquisition by Developing Murine Mesothelioma: Decreasing Bioavailable Copper Slows Tumor Growth, Normalizes Vessels and Promotes T Cell Infiltration
por: Crowe, Andrew, et al.
Publicado: (2013)

SOCS2 Influences LPS Induced Human Monocyte-Derived Dendritic Cell Maturation
por: Hu, Jin, et al.
Publicado: (2009)

Immature Dendritic Cells Generated from Cryopreserved Human Monocytes Show Impaired Ability to Respond to LPS and to Induce Allogeneic Lymphocyte Proliferation
por: Silveira, Guilherme Ferreira, et al.
Publicado: (2013)

CD8(+) cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy
por: Jackaman, Connie, et al.
Publicado: (2019)

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
por: Duong, Lelinh, et al.
Publicado: (2018)

Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis
por: Parlato, Stefania, et al.
Publicado: (2018)

Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-β
por: Bustamante, Marta F., et al.
Publicado: (2015)

Challenges in Acute Heart Failure Clinical Management: Optimizing Care Despite Incomplete Evidence and Imperfect Drugs
por: Teichman, Sam L., et al.
Publicado: (2015)

Severe re-expansion pulmonary edema despite incomplete re-expansion of the lung: a case report
por: Zabielna, Alicja
Publicado: (2021)

Hypoxia Shapes Autophagy in LPS-Activated Dendritic Cells
por: Monaci, Sara, et al.
Publicado: (2020)

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
por: Elahy, Mina, et al.
Publicado: (2015)

Monocyte derived dendritic cells generated by IFN-α acquire mature dendritic and natural killer cell properties as shown by gene expression analysis
por: Korthals, Mark, et al.
Publicado: (2007)

Role of IFN-γ and LPS on neuron/glial co-cultures infected by Neospora caninum
por: De Jesus, Erica Etelvina Viana, et al.
Publicado: (2014)

Response Profiles of BV2 Microglia to IFN-γ and LPS Co-Stimulation and Priming
por: Pan, Meng Liy, et al.
Publicado: (2023)

CD8(+) T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo
por: Ruedl, Christiane, et al.
Publicado: (1999)

The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I
por: Bridgeman, Stephanie, et al.
Publicado: (2021)

Characterization of the effect of LPS on dendritic cell subset discrimination in spleen
por: Griffiths, Kristin L, et al.
Publicado: (2014)

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non‐responders
por: Yang, Xiaodong, et al.
Publicado: (2020)

Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells
por: Chen, Kuang-Den, et al.
Publicado: (2011)

DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells
por: Sanecka, Anna, et al.
Publicado: (2011)

Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function
por: Guo, Bingnan, et al.
Publicado: (2021)

Mouse primary microglia respond differently to LPS and poly(I:C) in vitro
por: He, Yingbo, et al.
Publicado: (2021)

Human monocytes respond to lipopolysaccharide (LPS) stimulation in a sex‐dependent manner
por: Campesi, Ilaria, et al.
Publicado: (2021)

Incomplete Restoration of Angiotensin II - Induced Renal Extracellular Matrix Deposition and Inflammation Despite Complete Functional Recovery in Rats
por: Frenay, Anne-Roos S., et al.
Publicado: (2015)

Knockout of c‐Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation
por: Crotchett, Brandon L. M., et al.
Publicado: (2021)

Differential gene expression in LPS/IFNγ activated microglia and macrophages: in vitro versus in vivo
por: Schmid, Christoph D, et al.
Publicado: (2009)

The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model
por: Graham, Peter T., et al.
Publicado: (2022)

Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling
por: Bridgeman, Stephanie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q3ohdkn5demg6u3jamgcnujibk