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Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking Analysis
BACKGROUND: Anthracycline generates progressive left ventricular dysfunction associated with a poor prognosis. OBJECTIVES: The purpose of this study was to evaluate whether layer-specific strain analysis could assess the subclinical left ventricular dysfunction after exposure to anthracycline. METHO...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898770/ https://www.ncbi.nlm.nih.gov/pubmed/29694546 http://dx.doi.org/10.5935/abc.20180042 |
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author | Kang, Yu Xiao, Fei Chen, Haiyan Wang, Wei Shen, Lijing Zhao, Hang Shen, Xuedong Chen, Fangyuan He, Ben |
author_facet | Kang, Yu Xiao, Fei Chen, Haiyan Wang, Wei Shen, Lijing Zhao, Hang Shen, Xuedong Chen, Fangyuan He, Ben |
author_sort | Kang, Yu |
collection | PubMed |
description | BACKGROUND: Anthracycline generates progressive left ventricular dysfunction associated with a poor prognosis. OBJECTIVES: The purpose of this study was to evaluate whether layer-specific strain analysis could assess the subclinical left ventricular dysfunction after exposure to anthracycline. METHODS: Forty-two anthracycline-treated survivors of large B-cell non-Hodgkin lymphoma, aged 55.83 ± 17.92 years (chemotherapy group) and 27 healthy volunteers, aged 51.39 ± 13.40 years (control group) were enrolled. The cumulative dose of epirubicin in chemotherapy group was 319.67 ± 71.71mg/m(2). The time from last dose of epirubicin to the echocardiographic examination was 52.92 ± 22.32 months. Global longitudinal (GLS), circumferential (GCS) and radial strain (GRS), subendocardial, mid and subepicardial layer of longitudinal (LS-ENDO, LS-MID, LS-EPI) and circumferential strain (CS-ENDO, CS-MID, CS-EPI) values were analyzed. Transmural strain gradient was calculated as differences in peak systolic strain between the subendocardial and subepicardial layers. A value of p < 0.05 was considered significant. RESULTS: Conventional parameters of systolic and diastolic function showed no significant difference between two groups. Compared with controls, patients had significantly lower GCS and GLS. Multi-layer speckle tracking analysis showed significant reduction of circumferential strain of subendocardial layer, transmural CS gradient and longitudinal strain of all three layers. In contrast, the two groups did not differ in transmural longitudinal strain gradient and radial strains. CONCLUSIONS: It proved the preferential impairment of subendocardial deformation in long-term survivors after exposure to anthracycline. Multi-layer speckle tracking echocardiography might facilitate the longitudinal follow-up of this at-risk patient cohort. |
format | Online Article Text |
id | pubmed-5898770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58987702018-04-18 Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking Analysis Kang, Yu Xiao, Fei Chen, Haiyan Wang, Wei Shen, Lijing Zhao, Hang Shen, Xuedong Chen, Fangyuan He, Ben Arq Bras Cardiol Original Article BACKGROUND: Anthracycline generates progressive left ventricular dysfunction associated with a poor prognosis. OBJECTIVES: The purpose of this study was to evaluate whether layer-specific strain analysis could assess the subclinical left ventricular dysfunction after exposure to anthracycline. METHODS: Forty-two anthracycline-treated survivors of large B-cell non-Hodgkin lymphoma, aged 55.83 ± 17.92 years (chemotherapy group) and 27 healthy volunteers, aged 51.39 ± 13.40 years (control group) were enrolled. The cumulative dose of epirubicin in chemotherapy group was 319.67 ± 71.71mg/m(2). The time from last dose of epirubicin to the echocardiographic examination was 52.92 ± 22.32 months. Global longitudinal (GLS), circumferential (GCS) and radial strain (GRS), subendocardial, mid and subepicardial layer of longitudinal (LS-ENDO, LS-MID, LS-EPI) and circumferential strain (CS-ENDO, CS-MID, CS-EPI) values were analyzed. Transmural strain gradient was calculated as differences in peak systolic strain between the subendocardial and subepicardial layers. A value of p < 0.05 was considered significant. RESULTS: Conventional parameters of systolic and diastolic function showed no significant difference between two groups. Compared with controls, patients had significantly lower GCS and GLS. Multi-layer speckle tracking analysis showed significant reduction of circumferential strain of subendocardial layer, transmural CS gradient and longitudinal strain of all three layers. In contrast, the two groups did not differ in transmural longitudinal strain gradient and radial strains. CONCLUSIONS: It proved the preferential impairment of subendocardial deformation in long-term survivors after exposure to anthracycline. Multi-layer speckle tracking echocardiography might facilitate the longitudinal follow-up of this at-risk patient cohort. Sociedade Brasileira de Cardiologia - SBC 2018-03 /pmc/articles/PMC5898770/ /pubmed/29694546 http://dx.doi.org/10.5935/abc.20180042 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Yu Xiao, Fei Chen, Haiyan Wang, Wei Shen, Lijing Zhao, Hang Shen, Xuedong Chen, Fangyuan He, Ben Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking Analysis |
title | Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term
Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking
Analysis |
title_full | Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term
Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking
Analysis |
title_fullStr | Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term
Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking
Analysis |
title_full_unstemmed | Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term
Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking
Analysis |
title_short | Subclinical Anthracycline-Induced Cardiotoxicity in the Long - Term
Follow-Up of Lymphoma Survivors: A Multi-Layer Speckle Tracking
Analysis |
title_sort | subclinical anthracycline-induced cardiotoxicity in the long - term
follow-up of lymphoma survivors: a multi-layer speckle tracking
analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898770/ https://www.ncbi.nlm.nih.gov/pubmed/29694546 http://dx.doi.org/10.5935/abc.20180042 |
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